hemoglobin and hematocrit rise in end-stage renal disease (esrd) with pdpoetin: results of a phase ш, multicenter clinical trial
نویسندگان
چکیده
background and objective: the anemia of esrd is a complex disorder, associated with serious complications, which increases patients’ mortality and morbidity. treatment of this anemia with recombinant human erythropoietin (rh-epo) is well established. this clinical trial study was conducted within 20 months, from may 2005 to december 2006, in order to evaluate the efficacy of pdpoetin (rh-epo alpha manufactured in iran) in anemia correction of hemodialysis patients. materials and methods: the study population was composed of 80 patients, aged 22-84 years (with a mean of 49.5 ± 17.5 years), who were 60% male and 40% female. data were collected by using a questionnaire and a consent form is signed by each patient. all data analysis was carried out using spss software and statistical t-test. we administered 80-120 u/kg (up to 300 u/kg in resistant cases) of pdpoetin, 3 times per week, subcutaneously. then, we followed patients by weekly blood sampling for hct and hgb measurement. results: pdpoetin raised hct>1% and hgb>0.3 g/dl per week in 81% and 79% of patients with crpconclusion: pdpoetin may be an appropriate substitute for imported rh-epos. further research studies are recommended.
منابع مشابه
Hemoglobin And Hematocrit Rise In End-Stage Renal Disease (ESRD) With PDpoetin: Results Of A Phase Ш, Multicenter Clinical Trial
Background and Objective: The anemia of ESRD is a complex disorder, associated with serious complications, which increases patients’ mortality and morbidity. Treatment of this anemia with recombinant human erythropoietin (rh-EPO) is well established. This clinical trial study was conducted within 20 months, from May 2005 to December 2006, in order to evaluate the efficacy of PDpoetin (rh-EPO...
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عنوان ژورنال:
iranian journal of pathologyناشر: iranian society of pathology
ISSN 1735-5303
دوره 3
شماره 3 2008
کلمات کلیدی
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